Top 10 Hottest University Labs in Nanotech

The most recent issue of Nanotechnology Law and Business (NLB, Vol. 1, Issue 4) provides a top ten list of "hottest" nanotechnology university labs. NLB is a journal which explores the rapidly developing world of nanotechnology and miniaturization.

To date, efforts to commercialize nanoscale materials, devices, and systems have largely been driven by academic pioneers. Research labs at different universities across the country have been responsible for some of the most promising and disruptive breakthroughs in nanotechnology. With a substantial federal commitment to funding nanoscience and the construction of new nanoscience centers at numerous universities, professors, undergrads, graduate students, and post-docs will spend an increasing amount of their time and energy on understanding nanoscale phenomenon and developing new technologies in the coming years. In this issue, we review the ten hottest university labs in nanotechnology. We identified research groups that have not just made great scientific strides, but are also actively leading the way toward commercialization of nanotechnology.

The Ajayan Group, Rensselaer Polytechnic Institute

The Ajayan group is using carbon nanotubes as templates and molds for fabricating nanowires, composites, and novel ceramic fibers. The group’s research goals include producing macro-assemblies made of nanostructures for applications, understanding growth mechanisms of nanostructures and designing new structures and multifunctional nanocomposites. Other research interests are phase stability in metal clusters, the graphite-diamond phase transition, and growth of nanostructures under electron irradiation. Several start-ups have spun out of this group, and it collaborates with GE Global Research. The group is lead by Pulickel M. Ajayan, Professor of Materials Engineering at RPI.

The Alivisatos Group, UC Berkeley

Research in the Alivisatos group is primarily focused on nanocrystals. Alivisatos is Chancellor's Professor of Chemistry and Materials Science at UC Berkeley, Director of the Materials Sciences Division at the Lawrence Berkeley National Laboratory, and Director of the Molecular Foundry, a Department of Energy Nanoscale Science Research Center. Ongoing research projects in the Alivisatos group include nanocrystal / polymer composites for light emitting diodes and photovoltaics, and nanocrystal electron transistors, and nanocrystal/antibody conjugates as biological tag molecules, and DNA directed assembly of nanocrystal patterns. IP generated by this group relating to semiconductor nanomaterials is being developed at both Nanosys and its East Bay neighbor, Quantum Dot Corporation.

The Belcher Group, MIT

The Belcher group, which is comprised of 24 people, is exploring how to utilize biological systems to manufacture nanostructures. Angela Belcher’s research, which dates back to her days as a graduate student at UCSB, involves modifying viruses to produce nanowires, self-assembling films, and other nanomaterials. Cambrios Technologies Corp., the company formed to commercialize her technology, is currently seeking to raise money and is a hot topic in venture capital circles. Belcher, only 37, has received numerous honors, including Small Times’ 2002 innovator and researcher finalist awards; Beckman, DuPont and Army Young Investigator awards, and a Presidential Early Career Award. In September 2004, she was awarded a “genius grant” and the distinction of a MacArthur Fellow.

The Dai Group, Stanford University

The Dai group at Stanford University is likely to play a major role in the commercialization of carbon nanotubes. Dai discovered how to grow nanotubes in specific directions and orientations on substrates using a chemical vapor deposition process. His company, Molecular Nanosystems, holds intellectual property related to synthesis of nanotubes, nanotube sensors, and nanotubes as AFM tips. Nearly every academic and corporate research group working with carbon nanotubes has utilized Dai’s techniques.

The Lieber Group, Harvard University

Charlie Lieber’s goup is developing nanostructures for a variety of applications. The group’s research is primarily focused on self-assembly techniques for axial nanowire structures, radial nanowire structures, and branched nanowire structures, with device applications such as biological / chemical sensing & detection, digital electronics & computing, and photonics. Nanosys has licensed a substantial portion of the IP portfolio from Lieber’s lab. With funding from the Air Force, Army, Navy, DARPA, Ellison Medical Foundation, Intel Corporation, National Cancer Institute, and NSF, the Lieber group is likely to continue to make pioneering breakthroughs in the march toward commercialization of nanotechnology.

The Mirkin Group, Northwestern University

The Mirkin group focuses on developing methods for controlling the architecture of molecules and materials on the 1-100 nm length scale, and utilizing such structures in the development of analytical tools for chemical and biological sensing, lithography, catalysis, and optics. The Mirkin group pioneered the use of biomolecules as synthons in materials science and the development of nanoparticle-based biodiagnostics. Many of the concepts and materials developed within his laboratories are now the basis for commercial detection and lithography systems. Mirkin is the George B. Rathmann Professor of Chemistry and Director of the NU Institute for Nanotechnology. He is the inventor on over 50 patents, is an active consultant with several major chemical companies, and is the founder of two companies: Nanosphere and NanoInk.

The Quate Group, Stanford University

One of the most veteran research leaders on this list, Cal Quate has spent years developing imaging and lithography applications of scanning probes. He is a named inventor on 37 issued patents assigned to Stanford. Intellectual property developed by his group formed the basis for NanoDevices, a company that was acquired by Veeco. Quate’s IP has also been licensed to Molecular Nanosystems, and he sits on the scientific advisory board of the company. The Quate group is currently focused on increasing throughput by scanning simultaneously with multiple probes all moving at high speeds. Specifically, the group’s research involves the micromachining of cantilevers, fabrication of electron devices, system and circuit design, and the development and implementation of novel sensors and actuators.

The Roukes Group, Caltech

The Roukes group is developing and applying new techniques to create three-dimensional structures and machinery at the nanoscale. Roukes and his students have been pioneers in development of nanoelectromechanical systems. Roukes is the Director of Caltech’s Kavli Nanoscience Institute, cofounder of the Nanosystems Biology Alliance, co-founder and co-director of both the Initiative in Computational Molecular Biology and the Laboratory for Large Scale Integration of Nanostructures, and chair of the external advisory board of Harvard University’s nanoscience center. He recently teamed up with colleagues Yu-Chong Tai (Director of the Caltech Micromachining Laboratory) and Scott Fraser (Director of the Caltech Biological Imaging Center) to form Nanotechnica (division of Arrowhead Research Corporation), a company seeking to mass produce a variety of different nanoscale devices and systems.

The Smalley Group, Rice University

Perhaps the most important academic figure in the nanotech revolution is Richard Smalley, Professor of Chemistry and Professor of Physics & Astronomy at Rice University. Research in his lab lead to the discovery of the fullerene molecule and ultimately earned him a Nobel Prize in 1996. His current group is focused on single walled carbon nanotubes. The goal of the group is to develop methods of production, purification, derivitization, analysis, and assembly of nanotubes to solve real world problems. Carbon Nanotechnologies Inc., holder of the exclusive license to the suite of intellectual property developed in his lab, is developing a plant for mass production of single-walled carbon nanotubes.

The Whitesides Group, Harvard University

The Whitesides Group may be engaged in the most diverse and interdisciplinary areas of research of any group on this list, with projects stretching across biochemistry, materials science, catalysis, and physical organic chemistry. Ongoing projects include rational drug design, fabrication of nanostructures, microfluidic systems, soft lithography, fuel cells, and self-assembly of meso-scale systems. Perhaps the most vivid illustration of the impact that the Whitesides group could have on commercialization of nanotechnology is the role that graduate students played in guiding early efforts at Nanosys. Whitesides is the Mallinckrodt Professor of Chemistry at Harvard University and holds advisory positions with the National Science Foundation, National Research Council, and Department of Defense.

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